The reverse of our multipath setup post. Same assumptions: two iSCSI paths (110 and 111), interfaces named iscsi-110 and iscsi-111, TrueNAS on the other end. Some steps run on every node, some on one node only.
Proxmox UI
Datacenter → Storage → select the LVM storage → Remove
On a single node
# show which PV (mpath/WWID) maps to which VG
pvs -o pv_name,vg_name
# remove the VG and all its LVs
vgremove -f <vgname>
# remove the physical volume
pvremove /dev/mapper/<wwid>On all nodes
# list iscsi sessions to identify the target IQN
iscsiadm -m session# disconnect from the iscsi target
iscsiadm -m node -T <target_iqn> --logout
# delete the target record so it does not reconnect on reboot
iscsiadm -m node -T <target_iqn> -o deleteExample: removing general-vms and general-vms2
# general-vms
iscsiadm -m node -T iqn.2005-10.org.freenas.ctl:general-vms --logout
iscsiadm -m node -T iqn.2005-10.org.freenas.ctl:general-vms -o delete
# general-vms2
iscsiadm -m node -T iqn.2005-10.org.freenas.ctl:general-vms2 --logout
iscsiadm -m node -T iqn.2005-10.org.freenas.ctl:general-vms2 -o delete

